Vibsanin B preferentially targets HSP90β, inhibits interstitial leukocyte migration, and ameliorates experimental autoimmune encephalomyelitis.

Effect of vitamin D3 on leukocyte infiltration into the brain of C57/BL6 mice with experimental autoimmune encephalomyelitis

Background: Leukocyte infiltration into the central nervous system (CNS) in diseases like multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) have been implicated in subsequent disease pathogenesis and progression. It suggested that vitamin D3 (active form of vitamin D) ameliorates the symptoms of EAE when administered after the onset of clinical sings. The aim of this s...

Liver Damage and Mortality in a Male Lewis Rat of Experimental Autoimmune Encephalomyelitis

Background and Objectives: Multiple sclerosis is an inflammatory disease of the central nervous system. This is due to migration of peripherally activated lymphocytes to central nervous system leading to inflammatory lesions. However, liver has an anti-inflammatory microenvironment. Myelin expression in the liver of transgenic mice suppresses inflammatory lesions within central nervous system. ...

Nervous System of Encephalitogenic T Cells to the Central Encephalomyelitis by Impairing the Homing Experimental Autoimmune Inhibitory Factor Ameliorates Acute In Vivo Blockade of Macrophage Migration

Autoimmune Encephalomyelitis Onset Ameliorates Experimental of Encephalitogenic T Cells or After Disease Blockade of CD28 During In Vitro Activation

Th1-mediated experimental autoimmune encephalomyelitis is CXCR3 independent.

Drugs that block leukocyte trafficking ameliorate multiple sclerosis (MS). Occurrences of opportunistic infection, however, highlight the need for novel drugs that modulate more restricted subsets of T cells. In this context, chemokines and their receptors are attractive therapeutic targets. CXCR3, a Th1-associated chemokine receptor, is preferentially expressed on T cells that accumulate in MS...